Visión I+D
To carry out clinical trials and research projects with the aim of assessing the clinical and biochemical response of the lachrymal function unit to therapeutics or contact lens wear under controlled environmental conditions.
Servicios:  Diagnostic  and research services:
  • Advising in the design of protocols regarding ocular surface research projects and clinical trials.
  • Carring out clinical trials and research projects involving the lachrymal function unit.
  • Recruitment of dry eye patients for being included in clinical trials and research projects.
  • Editing of research papers detailing the clinical trials and research projects carried out previously in the CERLab.
During a conventional multicenter dry eye disease (DED) clinical trial, patients are daily exposed to variable temperature, relative humidity, draft and perform different visual tasks. Thus, the ocular surface of each participant is challenged differently, which is a major reason for failing to show statistically significant results in these therapeutic clinical trials.1 Environmental chambers are facilities where certain environmental conditions can be tightly controlled as well as visual tasks. They have been typically used to evaluate the response of an organism to a predetermined and controlled stimulus. DED signs and symptoms can be consistently exacerbated within the environmental chamber of the CERLab (IOBA, University of Valladolid, Spain); additionally, certain molecular biomarkers in tears or conjunctival cells are showing consistent up or down-regulation .2,3 Consequently, we are able to provide adequate facilities to reliably evaluate DED potential therapeutics.Additionally, contact lenses studies can be also performed in our facilities and we have already shown differences in tolerability in adverse environmental conditions.4
Our state-of-art facility and the expertise of our research team are suitable to customize clinical trial designs5 so that they can better show the efficacy of potential therapeutic candidates depending on each drug mechanism of action.
  1. Foulks GN. Challenges and pitfalls in clinical trials of treatments for dry eye. Ocul Surf. 2003;1:20-30.
  2. Tesón M, González-García MJ, López-Miguel A, Enríquez-de-Salamanca A, Martín-Montañez V, Mateo ME, Stern ME, Calonge M. Influence of a controlled environment simulating an in-flight airplane cabin on dry eye disease. Invest Ophthalmol Vis Sci. 2013;54:2093-9.
  3. López-Miguel A, Tesón M, Martín-Montañez V, Enríquez-de-Salamanca A, Stern ME, Calonge M, González-García MJ. Dry eye exacerbation in patients exposed to desiccating stress under controlled environmental conditions. Am J Ophthalmol. 2014;157:788-98
  4. González-García MJ, González-Sáiz A, de la Fuente B, San-José J, Feijó J, Stern ME, Calonge M. Exposure to a controlled adverse environment impairs the ocular surface of subjects with minimally symptomatic dry eye. Invest Ophthalmol Vis Sci. 2007;48:4026-32.
  5. Pinto-Fraga J, López-Miguel A, González-García MJ, Fernández I, López-de-la-Rosa A, Enríquez-de-Salamanca A, Stern ME, Calonge M. Topical Fluorometholone Protects the Ocular Surface of Dry Eye Patients from Desiccating  Stress: A Randomized Controlled Clinical Trial. Ophthalmology. 2016;123:141-53.


Contact:  How to request our services?
By e-mail or telephone:;; Tlf: 983184750 / 983186371.
Infraestructure: Major infrastructure and equipment:
Environmental chamber Facility able to control temperature, relative humidity, barometric pressure, illumination and air flow.
Video Slit lamp
Instrument used to evaluate the anterior segment of the eye.
Medmont E-300 topographer
Instrument used to characterize the shape of the ocular surface.
IRX-3 aberrometer
Instrument used to evaluate the higher order aberrations of the eye.
Osmometro Tearlab
Instrument used to quantify the tear film osmolarity.
Osmómetro Fiske
Instrument used to quantify the tear film osmolarity.
Belmonte esthesiometer Instrument used to quantify the mechanical and thermal sensitivity of the cornea.
Tearscope Instrument used to quantify the tear film break-up time.
CC-100XP Monitor
Instrument used to measure visual acuity and contrast sensitivity.
AS-220/C2 analytical balance
Instrument used to weigh contact lenses.